Rapid test for the diagnosis of visceral leishmaniasis in patients with suspected disease
Rapid diagnostic tests for visceral leishmaniasis
Marleen Boelaert1,*, Kristien Verdonck1,Joris Menten1,Temmy Sunyoto1,Johan van Griensven1,Francois Chappuis2, Suman Rijal3
1 Institute of Tropical Medicine, Antwerp, Belgium
2 Geneva University Hospitals, Division of International and Humanitarian Medicine, Geneva, Switzerland
3 BP Koirala Institute of Health Sciences, Department of Internal Medicine, Sunsari, Nepal
Boelaert M, Verdonck K, Menten J, Sunyoto T, van Griensven J, Chappuis F, Rijal S. Rapid tests for the diagnosis of visceral leishmaniasis in patients with suspected disease. Cochrane Database of Systematic Reviews 2014, Issue 6. Art. No.: CD009135.
To read the full review please follow this link: DOI: 10.1002/14651858.CD009135.pub2.
Visceral leishmaniasis (or kala-azar) is caused by a parasite, results in fever, a large spleen and other health problems, occurring in India, Bangladesh and Nepal, east Africa, the Mediterranean region and Brazil. Without treatment people die, and proper treatment can result in cure, so diagnosis is important. Many of the tests that are used to determine if a person has visceral leishmaniasis are complicated, costly, painful and sometimes dangerous for the patients. Now rapid diagnostic tests that are safe and easy to perform are available.
This Cochrane review describes how accurate these rapid diagnostic tests are for diagnosing visceral leishmaniasis. We summarize those studies that evaluated the rapid tests in people who, according to their physicians, could have the disease. We only included studies in which the researchers had used established methods to distinguish the people with visceral leishmaniasis from those who did not have the disease.
We found 24 studies, which contained information about five different rapid tests. A total of 4271 people participated in these studies. One of the rapid tests (called the rK39 immunochromatographic test) gave correct, positive results in 92% of the people with visceral leishmaniasis and it gave correct, negative results in 92% of the people who did not have the disease. This test worked better in India and Nepal than in east Africa. In India and Nepal, it gave correct, positive results in 97% of the people with the disease. In east Africa, it gave correct, positive results in only 85% of the people with the disease.
A second rapid test (called latex agglutination test) gave correct, positive results in 64% of the people with the disease and it gave correct, negative results in 93% of the people without the disease. For the other rapid tests evaluated, there are too few studies to know how accurate they are.